Carbonyls as Nucleophiles, Enolate Reactions

Reading & References

• Enolates, Aldol Condensation, Synthesis

Learning Goals

• Use of LDA to generate Enolate
  • LDA is a stronger base version of KOtBu, but still very bulky
• Relative reactivity between carbonyl compounds (esters vs ketones vs aldehydes)
• Reactivity of Enolates as Nucleophiles
  • Homocoupling Product
  • Heterocoupling product (The Aldol Reaction)
  • Condensation
    • Reflux vs Cold

Practice Problems

• Workbook Problems