Reduction of Carbonyl Compounds

Reading & References

• Reduction of Carbonyls
• Nucleophilic Addition of Grignards

Learning Goals

• LiAlH₄ reduction of Ketones and Aldehydes
  • Simple mechanism: Addition of Hydride, protonation of alkoxide
  • Importance of separating reaction into addition and the workup with an acid
• Grignard Reagents (R-MgBr)
  • Simple mechanism: Addition of Nucleophile (“R:^-“), protonation of alkoxide
  • Importance of separating reaction into addition and the workup with an acid

Practice Problems

• Workbook Problems